1982.09--1987.08 南通醫學(xue)院(yuan)醫療系(xi)醫學(xue)專業(ye)學(xue)習(本科)
1987.08--1993.09 南通醫(yi)(yi)學(xue)院(yuan)附屬醫(yi)(yi)院(yuan)心臟(zang)內科(ke)醫(yi)(yi)師(其間:1989.09--1992.07 南通醫(yi)(yi)學(xue)院(yuan)內科(ke)學(xue)專業(ye)學(xue)習,獲(huo)醫(yi)(yi)學(xue)碩士學(xue)位)
1993.09--1996.06 上海(hai)第(di)二醫科大學內科學專業博士研究(jiu)生
1996.07--1998.11 上海鐵道大學附屬甘泉醫(yi)院心臟內科主治(zhi)醫(yi)師
1998.11--2000.04 上(shang)海鐵道大學附屬甘泉(quan)醫(yi)院心臟內科副主任醫(yi)師(shi)
2000.04--2001.06 同濟(ji)大學附屬同濟(ji)醫(yi)院心臟(zang)內科副主任(ren)醫(yi)師
2001.06--2003.01 同濟大學附屬同濟醫(yi)院心臟內科副教授
2003.01--2008.12 同濟大學(xue)附屬(shu)同濟醫(yi)院心(xin)臟內科主任醫(yi)師、教授、博士生(sheng)導師 (其間:2007.04當(dang)選九三學(xue)社上海市委(wei)副主委(wei))
2008.12--2009.12 同濟大(da)學(xue)醫學(xue)院副院長
2009.12--2010.11 同(tong)濟大(da)學(xue)(xue)醫學(xue)(xue)院副院長、病理(li)學(xue)(xue)與(yu)病理(li)生理(li)學(xue)(xue)系主任(兼(jian))
2010.11--2011.11 同(tong)濟大(da)學醫學院副院長、病(bing)理(li)學與(yu)病(bing)理(li)生理(li)學系主任(兼(jian))、附屬東方醫院副院長(兼(jian))
2011.11--2016.02 同濟(ji)大(da)學(xue)醫(yi)學(xue)院(yuan)副院(yuan)長、病(bing)理生理學(xue)系主任(兼)、附屬東方醫(yi)院(yuan)副院(yuan)長(兼)、心律失常教育部(bu)重點實驗室(同濟(ji)大(da)學(xue))主任(其(qi)間:2013.02當選第十二屆全(quan)國(guo)政協委(wei)員;2015.12當選中國(guo)科學(xue)院(yuan)院(yuan)士)
2016.02--2016.11 同濟大學(xue)(xue)(xue)醫學(xue)(xue)(xue)院副院長、病理學(xue)(xue)(xue)與病理生理學(xue)(xue)(xue)系主任(兼)、附屬東(dong)方(fang)醫院副院長(兼)、心臟醫學(xue)(xue)(xue)部主任、心臟內科主任、心律失常(chang)診療中(zhong)心主任
2016.11--2017.12 同濟(ji)大學(xue)醫(yi)(yi)學(xue)與生命科學(xue)部主(zhu)任(ren)、病(bing)理(li)學(xue)與病(bing)理(li)生理(li)學(xue)系主(zhu)任(ren)(兼)、附屬(shu)東方醫(yi)(yi)院副院長(兼)、心(xin)(xin)臟醫(yi)(yi)學(xue)部主(zhu)任(ren)、心(xin)(xin)臟內科主(zhu)任(ren)、心(xin)(xin)律失常診療中心(xin)(xin)主(zhu)任(ren)
2017.12-- 同濟大學(xue)(xue)(xue)副(fu)校(xiao)長、醫(yi)(yi)學(xue)(xue)(xue)與生(sheng)命科(ke)(ke)學(xue)(xue)(xue)部主(zhu)任(ren)、病(bing)理學(xue)(xue)(xue)與病(bing)理生(sheng)理學(xue)(xue)(xue)系主(zhu)任(ren)(兼)、附(fu)屬東方(fang)醫(yi)(yi)院副(fu)院長(兼)、心臟(zang)醫(yi)(yi)學(xue)(xue)(xue)部主(zhu)任(ren)、心臟(zang)內科(ke)(ke)主(zhu)任(ren)、心律(lv)失常(chang)診療中心主(zhu)任(ren)
2005年(nian)07月:上海(hai)社(she)會主義學(xue)院培(pei)訓結業(ye)
2006年(nian)09月:中央社(she)會(hui)主(zhu)義學院進修(xiu)結業
2007年04月(yue):中國浦東干部學院研修結(jie)業
2007年(nian)09月:中(zhong)共上海市(shi)委黨校(xiao)培訓結業
2012年09月:中國(guo)井岡山干(gan)部(bu)學院培訓(xun)結業
2004-2004:美國凱斯西儲大學附屬(shu)醫院心臟內科(ke)客(ke)座教(jiao)授(shou)
2007-2009:同濟大(da)學附屬同濟醫院(yuan)心臟內科主任
2009-:同濟大(da)學附(fu)屬東(dong)方醫院心臟內科學科帶頭人(ren)
2008年(nian)起:同濟大學特聘教授
2015年12月(yue)7日,當選中(zhong)國科學院院士
1. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003; 299(5604): 251-254. (Corresponding Author)
2. Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, Liang B, Lin J, Liu Y, Liu B, Zhou Q, Zhang D, Wang R, Ma N, Su X, Niu K, Pei Y, Xu W, Chen Z, Wan H, Cui J, Barhanin J, Chen Y. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004; 75(5): 899-905. (Corresponding Author)
3. Yang YZ, Yang YQ, Liang B, Liu JQ, Li J, Grunnet M, Olesen SP, Rasmussen HB, Ellinor PT, Gao LJ, Lin XP, Li L, Wang L, Xiao JJ, Liu Y, Liu Y, Zhang SL, Liang DD, Peng LY, Jespersen T, Chen YH. Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet. 2010; 86(6): 872-880.(Corresponding Author)
4. Xiao J, Liang D, Chen YH. The genetics of atrial fibrillation: from the bench to the bedside. Annu Rev Genomics Hum Genet. 2011; 12(22): 73-96. (Corresponding Author)
5. Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen YH. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Res. 2014; 24(8):977-93. (Corresponding author)
6. Li J, Li CM, Zhang DS, Shi D, Qi M, Feng J, Yuan TY, Xu XR, Liang DD, Xu L, Zhang H, Liu Y, Chen JJ, Ye JC, Jiang WF, Cui YY, Zhang YY, Peng LY, Zhuo ZN, Chen YH. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nature Communications. 2014; 5: 5177.(Corresponding author)
7. Li J, Xie DY, Huang J, Lv F, Shi D, Liu Y, Lin L, Geng L, Wu YF, Liang DD, Chen YH. Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels. Cir Res. 2015; 8; 116(10): 1655-9. (Corresponding author)
8. Yang Y, Liu Y, Dong X, Kuang Y, Lin J, Su X, Peng L, Jin Q, He Y, Liu B, Pan Z, Li L, Zhu Q, Lin X, Zhou Q, Pan Q, Eurlings PMH, Fei J, Wang Z, Chen YH. Human KCNQ1 S140G mutation is associated with atrioventricular blocks. Heart Rhythm. 2007; 4(5): 611-618. (Corresponding Author)
9. Volders PG, Zhu Q, Timmermans C, Eurlings PM, Su X, Arens YH, Li L, Jongbloed RJ, Xia M, Rodriguez LM, Chen YH. Mapping a novel locus for familial atrial fibrillation on chromosome 10p11-q21. Heart Rhythm. 2007; 4(4): 469-475. (Corresponding Author)
10. Li J, Xiao J, Liu Y, Zhang G, Zhang H, Liang D, Liu Y, Zhang Y, Hu Y, Yu Z, Yan B, Jiang B, Peng L, Zhou ZN, Chen YH. Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogen against ischemic ventricular fibrillation. Pharmacol Res. 2009; 60(1): 61-67. (Corresponding Author)
11. Yang Y, Li J, Lin X, Yang Y, Hong K, Wang L, Liu J, Li L, Yan D, Liang D, Xiao J, Jin H, Wu J, Zhang Y, Chen YH. Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. J Hum Genet. 2009; 54(5): 277-283. (Corresponding Author)
12. Xiao JJ, Liang DD, Zhang H, Liu Y, Li FJ, Chen YH. 4’-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. Exp Biol Med. 2010; 235(4): 478-486. (Corresponding Author)
13. Li J, Xiao JJ, Liang DD, Zhang H, Zhang GF, Liu Y, Zhang YY, Liu Y, Yu Z, Yan B, Jiang B, Li F, Peng LY, Zhou ZN, Chen YH. Inhibition of mitochondrial translocator protein prevents atrial fibrillation. Eur J Pharmacol. 2010; 632(1-3): 60-64. (Corresponding Author)
14. Li J, Yan B, Huo ZX, Liu Y, Xu JH, Sun YF, Liu Y, Liang DD, Peng LY, Zhang YY, Zhou ZN, Shi JY, Cui JM, Chen YH. Beta2- but not beta1-adrenoceptor activation modulates intracellular oxygen availability. J Physiol. 2010; 588(16): 2987-2998. (Corresponding Author)
15. Li J, Xu J, Xiao J, Zhang H, Liang D, Liu Y, Zhang Y, Liu Y, Wen W, Hu Y, Yu Z, Yan B, Jiang B, Zhou ZN, Chen YH. Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity. J Cell Mol Med. 2011; 15(1): 134-140. (Corresponding Author)
16. Yan B, Huo Z, Liu Y, Lin X, Li J, Peng L, Zhao H, Zhou ZN, Liang X, Liu Y, Zhu W, Liang D, Li L, Sun Y, Cui J, Chen YH. Prolyl hydroxylase 2: A novel regulator of β2-adrenoceptor internalization. J Cell Mol Med. 2011; 15(12): 2712-2722. (Corresponding Author)
17. Xiao J, Liang D, Zhang Y, Liu Y, Zhang H, Liu Y, Li L, Liang X, Sun Y, Chen YH. MicroRNA expression signature in atrial fibrillation with mitral stenosis. Physiol Genomics. 2011; 43(11): 655-664. (Corresponding Author)
18. Xiao J, Jing ZC, Ellinor PT, Liang D, Zhang H, Liu Y, Chen X, Pan L, Lyon R, Liu Y, Peng LY, Liang X, Sun Y, Popescu LM, Condorelli G, Chen YH. MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism. J Transl Med. 2011; 24(9): 159. (Corresponding Author)
19. Xiao JJ, Liang DD, Liu Y, Zhang H, Liu Y, Zhao H, Li J, Peng LY, Zhou ZN, Chen YH. Taxol, a microtubule stabiliser, improves cardiac functional recovery during post-ischaemic reperfusion in rat in vitro. Cardiovasc Ther. 2012; 30(1): 12-30 (Corresponding Author)
20. Xiao J, Liang D, Zhang H, Liu Y, Zhang D, Liu Y, Pan L, Chen X, Doevendans PA, Sun Y, Liang X, Sluijter JP, Chen YH. MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells. J Mol Cell Cardiol. 2012; 53(6): 751-759. (Corresponding Author)
21. Li J, Zhang DS, Ye JC, Li CM, Qi M, Liang D, Xu XR, Xu L, Liu Y, Zhang H, Zhang Y,Deng F, Feng J, Shi D, Chen J, Li L, Chen G, Sun YF, Peng LY, Chen YH. Dynamin-2 mediates heart failure by modulating Ca2+-dependent cardiomyocyte apoptosis. Int J Cardiol. 2013; 168(3): 2109-2119. (Corresponding Author)
22. Li J, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH. Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis. J Cell Mol Med. 2013; 17(9): 1119-1127. (Corresponding author)
23. Li X, Jiang XY, Ge J, Wang J, Chen GJ, Xu L, Xie DY, Yuan TY, Zhang DS, Chen YH. Aberrantly expressed lncRNAs in Primary Varicose Great Saphenous Veins. PLoS one. 2014; 9: e86156. (Corresponding author)
24. Liang D, Xu X, Deng F, Feng J, Zhang H, Liu Y, Zhang Y, Pan L, Liu Y, Zhang D, Li J, Liang X, Sun Y, Xiao J, Chen YH. miRNA-940 reduction contributes to human Tetralogy of Fallot development. J Cell Mol Med. 2014; 18(9): 1830-1839. (Corresponding author)
25. Liang D, Zhen L, Yuan T, Huang J, Deng F, Wuyahan, Zhang H, Pan L, Liu Y, The E, Yu Z, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. miR-10a Regulates Proliferation of Human Cardiomyocyte Progenitor Cells by Targeting GATA6. PLoS One. 2014; 9(7): e103097. (Corresponding author)
26. Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. J Cell Mol Med. 2014; 18(10): 1992-1999. (Corresponding author)
27. Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM. HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013; 113(4): 399-407.
28. Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nature Communications. 2013; 4: 2812.
29. Zhang G, Yang H, Liang H, Yang J, Shi J, McFarland K, Chen Y, Cui J. A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. J Neurosci. 2014; 34(37): 12280-8.
陳(chen)義漢(han)教授(shou)長期從事心血管(guan)疾病臨床工作和(he)(he)基礎研究(jiu),臨床特長為(wei)心律失(shi)(shi)常(chang)和(he)(he)心力衰竭的(de)診斷和(he)(he)治療,研究(jiu)方向為(wei)心律失(shi)(shi)常(chang)和(he)(he)心力衰竭的(de)發生(sheng)機制和(he)(he)干(gan)預。在心律失(shi)(shi)常(chang)和(he)(he)心力衰竭研究(jiu)領域取(qu)得了一些重要(yao)的(de)科學發現。
以通(tong)訊作者身份(fen)在中國(guo)(guo)本土上發表(biao)SCI論文(wen)近(jin)50篇(pian),被SCI他(ta)引(yin)1000多(duo)次(ci),單篇(pian)SCI他(ta)引(yin)近(jin)500次(ci)。標志性(xing)成果發表(biao)在《Science》、《Nature Communications》、《Am J Hum Genet》、《Annu Rev Genomics Hum Genet》、《Cell Res》和(he)《Circulation Research》等(deng)權威(wei)刊物上。他(ta)的科(ke)學(xue)發現(xian)(xian)已(yi)經(jing)被寫進了50多(duo)本國(guo)(guo)外(wai)教科(ke)書和(he)專著,國(guo)(guo)際(ji)診療指南多(duo)次(ci)引(yin)用(yong)他(ta)的工作,多(duo)種遺傳性(xing)心(xin)律失(shi)常是依據他(ta)的發現(xian)(xian)而分(fen)類(lei)。他(ta)的科(ke)學(xue)發現(xian)(xian)也曾經(jing)被評(ping)為國(guo)(guo)際(ji)心(xin)臟電(dian)生理學(xue)領域年(nian)度突(tu)破性(xing)進展和(he)中國(guo)(guo)高(gao)等(deng)學(xue)校十大科(ke)技進展等(deng)。
2003年(nian),陳(chen)義漢在(zai)(zai)國(guo)際(ji)上首次發現人(ren)類心房顫動(dong)致(zhi)病基(ji)因,鑒定出人(ren)類心房顫動(dong)的部(bu)分遺傳學(xue)和電生理學(xue)機制(zhi),成(cheng)果發表于(yu)《科(ke)學(xue)》雜(za)志。此后他帶領團隊(dui)在(zai)(zai)心房顫動(dong)等心律失常(chang)的機制(zhi)和干預研究方向(xiang)上取得(de)一系列重要(yao)發現,為中國(guo)在(zai)(zai)國(guo)際(ji)心律失常(chang)研究領域贏得(de)了一席(xi)之(zhi)地。
國(guo)(guo)家(jia)(jia)自(zi)然科(ke)(ke)(ke)學獎(jiang)二等獎(jiang)(第(di)一(yi)完(wan)成(cheng)人(ren)(ren))(2005年(nian)(nian)(nian)(nian)(nian)(nian))、教(jiao)育(yu)部(bu)自(zi)然科(ke)(ke)(ke)學獎(jiang)一(yi)等獎(jiang)(第(di)一(yi)完(wan)成(cheng)人(ren)(ren))(2004年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市自(zi)然科(ke)(ke)(ke)學獎(jiang)一(yi)等獎(jiang)(第(di)一(yi)完(wan)成(cheng)人(ren)(ren))(2011年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市自(zi)然科(ke)(ke)(ke)學牡丹獎(jiang)(2009年(nian)(nian)(nian)(nian)(nian)(nian))、國(guo)(guo)家(jia)(jia)973計劃(hua)首席科(ke)(ke)(ke)學家(jia)(jia)(2012年(nian)(nian)(nian)(nian)(nian)(nian))、國(guo)(guo)家(jia)(jia)杰出青年(nian)(nian)(nian)(nian)(nian)(nian)科(ke)(ke)(ke)學基金(jin)獲(huo)得(de)(de)者(zhe)(2004年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市領軍人(ren)(ren)才(2005年(nian)(nian)(nian)(nian)(nian)(nian))、中(zhong)國(guo)(guo)醫師獎(jiang)(2006年(nian)(nian)(nian)(nian)(nian)(nian))、新世(shi)紀百千(qian)萬人(ren)(ren)才工(gong)程國(guo)(guo)家(jia)(jia)級(ji)人(ren)(ren)選(2006年(nian)(nian)(nian)(nian)(nian)(nian))、教(jiao)育(yu)部(bu)創(chuang)新團隊負責人(ren)(ren)(2007年(nian)(nian)(nian)(nian)(nian)(nian))、國(guo)(guo)家(jia)(jia)創(chuang)新研究(jiu)群(qun)體負責人(ren)(ren)(2012)、中(zhong)國(guo)(guo)青年(nian)(nian)(nian)(nian)(nian)(nian)科(ke)(ke)(ke)技獎(jiang)(2005年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市優(you)秀學科(ke)(ke)(ke)帶頭人(ren)(ren)(2005年(nian)(nian)(nian)(nian)(nian)(nian))、衛(wei)生(sheng)部(bu)有突出貢獻(xian)的中(zhong)青年(nian)(nian)(nian)(nian)(nian)(nian)專家(jia)(jia)(2004年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市優(you)秀專業技術人(ren)(ren)才(2003年(nian)(nian)(nian)(nian)(nian)(nian))、國(guo)(guo)務院特殊津貼獲(huo)得(de)(de)者(zhe)(2004年(nian)(nian)(nian)(nian)(nian)(nian))、上(shang)海(hai)(hai)(hai)市勞(lao)動模范(2001-2003年(nian)(nian)(nian)(nian)(nian)(nian)度(du);2004-2006年(nian)(nian)(nian)(nian)(nian)(nian)度(du))、全(quan)國(guo)(guo)五(wu)一(yi)勞(lao)動獎(jiang)章獲(huo)得(de)(de)者(zhe)(2006年(nian)(nian)(nian)(nian)(nian)(nian))。
2020年2月19日,入選國(guo)家健康科普專家庫。