乳(ru)腺(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)是由(you)腺(xian)(xian)(xian)(xian)上(shang)(shang)皮(pi)和纖(xian)(xian)維(wei)(wei)(wei)組(zu)(zu)織(zhi)(zhi)(zhi)兩種(zhong)成(cheng)(cheng)分混合組(zu)(zu)成(cheng)(cheng)的(de)(de)良性(xing)(xing)腫瘤(liu)(liu)(liu),好發(fa)于(yu)青年女性(xing)(xing),與(yu)患(huan)者(zhe)體(ti)內(nei)(nei)性(xing)(xing)激素水平失衡(heng)有(you)關。對本病的(de)(de)認識(shi)還(huan)有(you)腺(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)瘤(liu)(liu)(liu)、腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)之稱,是由(you)于(yu)構成(cheng)(cheng)腫瘤(liu)(liu)(liu)的(de)(de)纖(xian)(xian)維(wei)(wei)(wei)成(cheng)(cheng)分和腺(xian)(xian)(xian)(xian)上(shang)(shang)皮(pi)增生(sheng)程度的(de)(de)不(bu)同所(suo)致(zhi)。當腫瘤(liu)(liu)(liu)構成(cheng)(cheng)以腺(xian)(xian)(xian)(xian)上(shang)(shang)皮(pi)增生(sheng)為(wei)(wei)主,而(er)纖(xian)(xian)維(wei)(wei)(wei)成(cheng)(cheng)分較(jiao)少(shao)時(shi)稱為(wei)(wei)纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu);若纖(xian)(xian)維(wei)(wei)(wei)組(zu)(zu)織(zhi)(zhi)(zhi)在腫瘤(liu)(liu)(liu)中占多數,腺(xian)(xian)(xian)(xian)管(guan)成(cheng)(cheng)分較(jiao)少(shao)時(shi),稱為(wei)(wei)腺(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)瘤(liu)(liu)(liu);腫瘤(liu)(liu)(liu)組(zu)(zu)織(zhi)(zhi)(zhi)由(you)大量腺(xian)(xian)(xian)(xian)管(guan)成(cheng)(cheng)分組(zu)(zu)成(cheng)(cheng)時(shi),則稱為(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)。上(shang)(shang)述三種(zhong)分類只是病理形(xing)態學(xue)方面的(de)(de)差異(yi),其臨(lin)床(chuang)表現、治(zhi)療及預后并(bing)無不(bu)同,故統稱為(wei)(wei)纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)。乳(ru)腺(xian)(xian)(xian)(xian)纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)好發(fa)于(yu)乳(ru)房外上(shang)(shang)象限,呈圓(yuan)形(xing)或卵圓(yuan)形(xing),臨(lin)床(chuang)多見(jian)1~3cm,生(sheng)長緩慢,妊(ren)娠或哺乳(ru)期時(shi)可急驟增長。極少(shao)數青春期發(fa)生(sheng)的(de)(de)纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)可在短時(shi)間內(nei)(nei)迅速(su)增大,直徑可達8~10cm,稱為(wei)(wei)巨大纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu),仍屬良性(xing)(xing)腫瘤(liu)(liu)(liu)。纖(xian)(xian)維(wei)(wei)(wei)腺(xian)(xian)(xian)(xian)瘤(liu)(liu)(liu)惡變成(cheng)(cheng)纖(xian)(xian)維(wei)(wei)(wei)肉瘤(liu)(liu)(liu)或乳(ru)腺(xian)(xian)(xian)(xian)癌者(zhe)極少(shao)見(jian),不(bu)到1%。
卵(luan)巢功能旺(wang)盛(sheng),雌(ci)激(ji)素(su)水平(ping)過(guo)高,調節失(shi)衡,加之患(huan)者對雌(ci)激(ji)素(su)反(fan)應敏感,在(zai)雌(ci)激(ji)素(su)的長期刺(ci)激(ji)下,引起乳腺腺上皮組(zu)織和纖維(wei)組(zu)織過(guo)度增生,結構紊亂(luan),形(xing)成腫瘤。由于乳腺纖維(wei)腺瘤與性激(ji)素(su)分泌旺(wang)盛(sheng)有關,故(gu)此多發生在(zai)青年女性,月經來潮前(qian)或絕經后(hou)婦女少見。
主要為乳(ru)房(fang)無痛(tong)性(xing)腫(zhong)塊,很少伴(ban)有(you)乳(ru)房(fang)疼(teng)痛(tong)或乳(ru)頭溢液。腫(zhong)塊往(wang)往(wang)是(shi)無意(yi)中、洗澡(zao)時,或體檢中被發(fa)現(xian)。單發(fa)腫(zhong)塊居多,亦可多發(fa),也(ye)可兩側乳(ru)房(fang)同時或先后(hou)觸及腫(zhong)塊。多為圓形(xing)或橢圓形(xing),直徑常為1~3cm,亦有(you)更小或更大(da)者,偶可見巨大(da)者。境(jing)界清楚,邊緣整齊,表(biao)面(mian)光滑,富有(you)彈(dan)性(xing),無壓(ya)痛(tong),活動度(du)較(jiao)大(da),與皮(pi)膚無粘連。
1.彩超
能顯(xian)示乳(ru)房(fang)各層次結構及腫(zhong)(zhong)(zhong)塊形態、大小及回(hui)聲(sheng)狀況。乳(ru)腺纖(xian)維腺瘤彩超多(duo)(duo)為圓形、卵圓形均(jun)勻低回(hui)聲(sheng)腫(zhong)(zhong)(zhong)物,多(duo)(duo)可(ke)見(jian)(jian)光滑清(qing)晰的包(bao)膜回(hui)聲(sheng),腫(zhong)(zhong)(zhong)塊后方回(hui)聲(sheng)正常或(huo)輕微增強,可(ke)見(jian)(jian)側方聲(sheng)影(ying),腫(zhong)(zhong)(zhong)塊內(nei)可(ke)見(jian)(jian)伴聲(sheng)影(ying)的粗大鈣化。彩色多(duo)(duo)普勒顯(xian)示腫(zhong)(zhong)(zhong)塊內(nei)多(duo)(duo)無血流信號或(huo)見(jian)(jian)少量血流信號,RI<0.7。
2.乳(ru)腺X線攝影
青(qing)春期女(nv)(nv)孩,致(zhi)密型乳腺,不適宜進行乳腺X線攝(she)影。中年及以(yi)上婦女(nv)(nv)乳腺X線片纖(xian)維(wei)腺瘤表現為圓形、卵圓形腫(zhong)(zhong)塊,也可呈分葉狀(zhuang),直徑多為1~3cm,邊緣(yuan)光滑清楚,與(yu)等(deng)體積的正常腺體比較,腫(zhong)(zhong)塊呈等(deng)或(huo)稍高(gao)密度,周圍可有低密度暈環。部(bu)分病灶內可見鈣化,鈣化多位(wei)于腫(zhong)(zhong)塊中心或(huo)邊緣(yuan),多呈粗顆(ke)粒狀(zhuang)、樹枝狀(zhuang)或(huo)斑點狀(zhuang),也可相互融合成大塊狀(zhuang),占據(ju)腫(zhong)(zhong)塊大部(bu)或(huo)全(quan)部(bu),與(yu)乳腺癌的成簇(cu)沙粒樣鈣化灶不同。
3.乳腺病灶活檢
根(gen)據病史、體檢(jian)或(huo)影像學檢(jian)查(cha)難以鑒別的乳(ru)腺腫塊,可采取穿刺(ci)或(huo)手術(shu)切除的方法,進(jin)行組織病理學檢(jian)查(cha),明確診(zhen)斷。
乳(ru)(ru)房位于(yu)體表(biao),典型的(de)乳(ru)(ru)腺(xian)纖維腺(xian)瘤(liu)相對容易診斷(duan)。青少年女性(xing),無(wu)(wu)意中或(huo)體檢中發現乳(ru)(ru)房無(wu)(wu)痛(tong)性(xing)腫(zhong)塊(kuai)1~3cm,圓(yuan)形或(huo)卵圓(yuan)形,與(yu)周(zhou)圍無(wu)(wu)粘連,活動(dong)度大,觸(chu)診有滑脫感;生長緩慢,與(yu)月經周(zhou)期無(wu)(wu)關;臨(lin)床可考慮為乳(ru)(ru)腺(xian)纖維腺(xian)瘤(liu)。但(dan)對于(yu)妊娠后,特別(bie)是絕經后婦女,乳(ru)(ru)房發現無(wu)(wu)痛(tong)性(xing)腫(zhong)塊(kuai),要(yao)提高(gao)警惕(ti),不(bu)要(yao)輕易診斷(duan)乳(ru)(ru)腺(xian)纖維腺(xian)瘤(liu),應借(jie)助影像(xiang)學檢查鑒別(bie)診斷(duan),必要(yao)時需(xu)依(yi)據病(bing)理組織學檢查確診。
1.密切觀(guan)察、定期隨診
乳腺(xian)纖維腺(xian)瘤是常見的良性腫瘤,極少(shao)惡變。發展緩慢,沒有(you)癥(zheng)狀,不(bu)影響生活和工作(zuo),可以(yi)密切觀察定期(qi)隨診。
2.外科手(shou)術(shu)切(qie)除(chu)
(1)觀(guan)察過程中,如乳房(fang)自查或去醫院檢查,發現纖維腺瘤有增大(da)傾(qing)向,或彩超原顯示腫塊內無血流(liu)信號(hao)現可見大(da)量血流(liu)信號(hao),應手(shou)術切除。
(2)乳(ru)腺(xian)纖維瘤患(huan)者,準備(bei)懷孕之(zhi)前,應(ying)進行(xing)纖維腺(xian)瘤切除術(shu)。原因:a.乳(ru)腺(xian)纖維腺(xian)瘤的發(fa)生(sheng)與雌激素水平升高(gao)有(you)關,妊娠、哺(bu)乳(ru)期(qi),隨(sui)著體內激素水平的變化,可(ke)導致腫瘤體積迅速增大。b.妊娠期(qi)乳(ru)腺(xian)不(bu)宜進行(xing)手術(shu)及有(you)創性檢(jian)查,哺(bu)乳(ru)期(qi)亦不(bu)適合手術(shu)。
(3)青(qing)少年巨大(da)纖(xian)(xian)維腺瘤(幼年性纖(xian)(xian)維腺瘤),因腫瘤生長快,體(ti)積(ji)大(da),對正(zheng)常乳(ru)腺組織產生擠壓,應考慮手術切除(chu),手術不(bu)會對以后(hou)的妊(ren)娠(shen)、哺乳(ru)產生不(bu)良影響。
(4)有乳腺癌家族(zu)史者可考慮(lv)手術切除。
3.乳(ru)腺微創旋切手術
選擇乳腺纖維(wei)腺瘤診斷明確者(不適宜乳腺癌的治療(liao))。利用真空輔助旋切(qie)(qie)設備,在乳腺超聲引導(dao)下(xia),一次進針多次切(qie)(qie)割將(jiang)腫瘤切(qie)(qie)除。切(qie)(qie)口僅0.3cm,恢(hui)復(fu)(fu)快,美(mei)學(xue)效果好。纖維(wei)腺瘤完整(zheng)切(qie)(qie)除后很少復(fu)(fu)發(fa),但(dan)可再(zai)發(fa)。
建(jian)立(li)良好地生活飲(yin)食習慣,避免(mian)和減(jian)少心理(li)緊張因素(su),保(bao)持心情舒暢。控(kong)制(zhi)高脂肪(fang)、高熱量飲(yin)食的(de)攝入,不(bu)亂服用(yong)外源(yuan)性雌激(ji)素(su)。掌握乳(ru)房自我(wo)檢查(cha)方法,養成每月一(yi)次的(de)乳(ru)房自查(cha)習慣,若(ruo)發現原(yuan)因不(bu)明的(de)乳(ru)腺(xian)(xian)結節,應及時去醫院診斷(duan)。積極(ji)參(can)加乳(ru)腺(xian)(xian)癌篩查(cha)。