功能性子宮出(chu)血,簡稱功(gong)(gong)血,這(zhe)種疾病是由(you)于下(xia)丘腦-垂(chui)體-卵(luan)(luan)巢(chao)(H-P-O)軸(zhou)異常(chang)調節(jie)引(yin)起(qi)的(de)(de)神(shen)經(jing)內分泌(mi)異常(chang)引(yin)發的(de)(de)非(fei)正(zheng)常(chang)子宮(gong)出(chu)血的(de)(de)非(fei)器(qi)質性病變。功(gong)(gong)血是婦科常(chang)見疾病,約(yue)占婦科門診(zhen)患者的(de)(de)10%。臨床上將(jiang)這(zhe)種疾病分為兩種,即(ji)無(wu)排(pai)卵(luan)(luan)型功(gong)(gong)血和(he)排(pai)卵(luan)(luan)型功(gong)(gong)血。前(qian)一(yi)種,常(chang)發生于青春期(qi)和(he)絕(jue)經(jing)過渡期(qi)婦女(nv)。青春期(qi)功(gong)(gong)能性子宮(gong)出(chu)血是由(you)于神(shen)經(jing)內分泌(mi)中(zhong)樞發育不全或成熟延(yan)遲(chi)所(suo)致(zhi)。絕(jue)經(jing)婦女(nv)出(chu)現的(de)(de)功(gong)(gong)血主要(yao)是由(you)于下(xia)丘腦-垂(chui)體-卵(luan)(luan)巢(chao)軸(zhou)功(gong)(gong)能減(jian)退(tui),是卵(luan)(luan)巢(chao)功(gong)(gong)能不斷衰退(tui)而(er)引(yin)起(qi)。
一般(ban)認為,機體內外許多(duo)因素如精神過(guo)(guo)度緊張、恐懼、憂傷(shang)、環境和(he)氣候(hou)的(de)驟變、過(guo)(guo)度勞累(lei)及其他全(quan)身性疾病,均(jun)可(ke)通過(guo)(guo)大腦(nao)皮(pi)層(ceng)的(de)神經(jing)遞(di)質影響(xiang)下(xia)丘腦(nao)-垂體-卵(luan)巢軸的(de)相互調節,導致(zhi)卵(luan)巢功能失調,而致(zhi)月(yue)經(jing)紊亂。營養不良、貧血及代射紊亂也可(ke)影響(xiang)激素的(de)合成、轉(zhuan)運和(he)對靶器(qi)官的(de)效應而導致(zhi)月(yue)經(jing)失調。
無卵(luan)(luan)功(gong)血(xue)是在激素的(de)(de)調解下,導致子宮(gong)(gong)內(nei)(nei)膜(mo)微環境(jing)(包括生長因子、細(xi)胞(bao)因子、血(xue)管活性物質、細(xi)胞(bao)外(wai)基(ji)質等)改(gai)變(bian)。子宮(gong)(gong)內(nei)(nei)膜(mo)微環境(jing)的(de)(de)改(gai)變(bian),導致子宮(gong)(gong)內(nei)(nei)膜(mo)的(de)(de)修復失控,出現病理性改(gai)變(bian),導致無卵(luan)(luan)性功(gong)血(xue)的(de)(de)發生。
而對(dui)于(yu)青春(chun)期(qi)功(gong)血是因(yin)為缺(que)乏孕酮對(dui)抗和(he)腺(xian)體(ti)分泌(mi)化(hua);PC升(sheng)高(gao);凝血因(yin)子V、VII、X、XII等(deng)的(de)缺(que)乏以及螺旋小(xiao)動(dong)脈和(he)溶酶體(ti)作用子宮內膜螺旋小(xiao)動(dong)脈和(he)溶酶體(ti)結構和(he)功(gong)能異(yi)常(chang),影響內膜脫(tuo)落和(he)血管上(shang)皮(pi)的(de)修復等(deng)。
在臨床實踐中,功(gong)(gong)血(xue)(xue)(xue)的(de)準確診(zhen)(zhen)斷(duan)并(bing)不容易(yi),有(you)報道(dao)一(yi)些器(qi)質(zhi)性(xing)(xing)(xing)病(bing)(bing)(bing)(bing)變(bian)比較隱蔽,病(bing)(bing)(bing)(bing)程緩慢(man),被(bei)誤(wu)診(zhen)(zhen)為(wei)功(gong)(gong)血(xue)(xue)(xue)。診(zhen)(zhen)斷(duan)功(gong)(gong)血(xue)(xue)(xue),第(di)一(yi),要除外(wai)器(qi)質(zhi)性(xing)(xing)(xing)病(bing)(bing)(bing)(bing)變(bian)。器(qi)質(zhi)性(xing)(xing)(xing)病(bing)(bing)(bing)(bing)變(bian)有(you)很多種,如血(xue)(xue)(xue)小板減少癥,再障血(xue)(xue)(xue)液(ye)病(bing)(bing)(bing)(bing),甲低,甲亢,服(fu)用性(xing)(xing)(xing)激(ji)素,避孕藥,生殖器(qi)外(wai)傷,異物,異位妊娠,先兆流(liu)產,子宮(gong)(gong)(gong)(gong)(gong)平滑肌(ji)瘤(liu)和(he)肉瘤(liu)、子宮(gong)(gong)(gong)(gong)(gong)腺肌(ji)病(bing)(bing)(bing)(bing)、子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)癌、子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)炎、子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)息肉,紅斑狼(lang)瘡等。第(di)二(er),長期功(gong)(gong)能(neng)性(xing)(xing)(xing)失調可(ke)能(neng)會轉化為(wei)器(qi)質(zhi)性(xing)(xing)(xing),兩者并(bing)無絕對界限,如無排(pai)卵功(gong)(gong)血(xue)(xue)(xue)的(de)患(huan)(huan)者由(you)于受體內(nei)高(gao)雌激(ji)素的(de)影響轉為(wei)子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)息肉,子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)癌。臨床多見反復異常子宮(gong)(gong)(gong)(gong)(gong)出血(xue)(xue)(xue)的(de)患(huan)(huan)者,早期診(zhen)(zhen)刮術后病(bing)(bing)(bing)(bing)理是增生期內(nei)膜(mo),因(yin)未按時復診(zhen)(zhen)及正(zheng)確治療,后期診(zhen)(zhen)刮術后病(bing)(bing)(bing)(bing)理診(zhen)(zhen)斷(duan)為(wei)子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)癌。第(di)三,導致異常子宮(gong)(gong)(gong)(gong)(gong)出血(xue)(xue)(xue)的(de)器(qi)質(zhi)性(xing)(xing)(xing)病(bing)(bing)(bing)(bing)變(bian)和(he)功(gong)(gong)能(neng)性(xing)(xing)(xing)障礙可(ke)能(neng)并(bing)存。功(gong)(gong)血(xue)(xue)(xue)的(de)患(huan)(huan)者可(ke)能(neng)同(tong)時患(huan)(huan)有(you)其他疾病(bing)(bing)(bing)(bing),如功(gong)(gong)血(xue)(xue)(xue)與(yu)(yu)內(nei)膜(mo)炎并(bing)存,功(gong)(gong)血(xue)(xue)(xue)與(yu)(yu)子宮(gong)(gong)(gong)(gong)(gong)肌(ji)瘤(liu)并(bing)存,功(gong)(gong)血(xue)(xue)(xue)與(yu)(yu)子宮(gong)(gong)(gong)(gong)(gong)內(nei)膜(mo)異位癥并(bing)存等。
目前輔(fu)助檢(jian)(jian)查(cha)功(gong)(gong)能(neng)性(xing)子宮出(chu)血的手(shou)段包(bao)括診斷性(xing)刮宮、排卵和黃體功(gong)(gong)能(neng)檢(jian)(jian)測(包(bao)括基礎體溫的測定(ding)、陰道細胞學和宮頸粘液(ye)功(gong)(gong)能(neng)的檢(jian)(jian)查(cha)、激素的測定(ding)、超聲檢(jian)(jian)查(cha))、血液(ye)和凝血纖(xian)溶功(gong)(gong)能(neng)檢(jian)(jian)查(cha)、肝(gan)功(gong)(gong)能(neng)檢(jian)(jian)查(cha)。
功血診(zhen)斷的(de)要點:應準確地采集病(bing)(bing)(bing)史,詳細(xi)詢(xun)問月經和(he)出(chu)血史,近期服用避孕藥及性激素藥物,判斷不正常月經的(de)出(chu)血類型。婦科檢(jian)查可排除(chu)宮(gong)頸(jing)疾病(bing)(bing)(bing)、陰道疾病(bing)(bing)(bing)引起的(de)出(chu)血,明確子宮(gong)腔出(chu)血。育(yu)齡期婦女檢(jian)查人(ren)絨(rong)毛膜(mo)促性腺(xian)激素排除(chu)妊(ren)娠相關疾病(bing)(bing)(bing)。超(chao)聲(sheng)影像學檢(jian)查排除(chu)生殖系(xi)統器質性病(bing)(bing)(bing)變。診(zhen)斷性刮(gua)宮(gong)排除(chu)子宮(gong)內膜(mo)增生性疾病(bing)(bing)(bing)或癌前(qian)病(bing)(bing)(bing)變。宮(gong)腔鏡(jing)檢(jian)查和(he)子宮(gong)內膜(mo)活檢(jian)是有效的(de)診(zhen)斷手段。
臨床上對于功血的治療,西(xi)醫主要采取刮宮和激素藥物治療。
對于已婚婦女(nv),多采(cai)用(yong)刮宮治療的(de)方(fang)法(fa),通過刮宮,能夠起到(dao)快速止血的(de)目的(de),并(bing)且刮出物可(ke)以作為病理檢驗的(de)標本,起到(dao)雙重功效。性(xing)激素(su)也可(ke)以應(ying)用(yong)其中,起到(dao)止血的(de)作用(yong),目前常(chang)用(yong)的(de)激素(su)包括雌激素(su)、雄(xiong)激素(su)、孕激素(su)。
對于(yu)青春期功血(xue)(xue)(xue)(xue)(xue)且(qie)貧(pin)血(xue)(xue)(xue)(xue)(xue)不嚴(yan)重(zhong)者(Hb>=80g/L),可(ke)(ke)應用大(da)(da)劑(ji)量(liang)的(de)(de)(de)(de)雌激(ji)(ji)素(su)(su)(su),雌激(ji)(ji)素(su)(su)(su)能(neng)夠(gou)刺激(ji)(ji)子(zi)宮內(nei)(nei)膜增(zeng)生(sheng),使得創面得以(yi)修復,但是停(ting)藥后可(ke)(ke)引起更(geng)嚴(yan)重(zhong)的(de)(de)(de)(de)出血(xue)(xue)(xue)(xue)(xue),并(bing)且(qie)胃腸道反應比較(jiao)嚴(yan)重(zhong)。孕激(ji)(ji)素(su)(su)(su)適用于(yu)各(ge)類型的(de)(de)(de)(de)出血(xue)(xue)(xue)(xue)(xue),能(neng)夠(gou)促進子(zi)宮內(nei)(nei)膜同步性(xing)分(fen)泌化,以(yi)達到(dao)止(zhi)血(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)目(mu)的(de)(de)(de)(de)。藥物性(xing)刮宮適用于(yu)淋漓出血(xue)(xue)(xue)(xue)(xue)而無大(da)(da)出血(xue)(xue)(xue)(xue)(xue)者,通(tong)過(guo)使用孕酮使內(nei)(nei)膜在短期內(nei)(nei)分(fen)泌化并(bing)集中撤退。以(yi)上(shang)服(fu)用孕激(ji)(ji)素(su)(su)(su)者,均需要從撤退性(xing)出血(xue)(xue)(xue)(xue)(xue)第五天(tian)開始進行(xing)調經治(zhi)療(liao)。雄激(ji)(ji)素(su)(su)(su)作為雌、孕激(ji)(ji)素(su)(su)(su)止(zhi)血(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)輔助療(liao)法,目(mu)的(de)(de)(de)(de)是抗(kang)雌激(ji)(ji)素(su)(su)(su),減少盆腔(qiang)充(chong)血(xue)(xue)(xue)(xue)(xue)和增(zeng)強子(zi)宮肌(ji)張(zhang)力并(bing)減少出血(xue)(xue)(xue)(xue)(xue)量(liang),但不能(neng)縮短出血(xue)(xue)(xue)(xue)(xue)時(shi)間和完全止(zhi)血(xue)(xue)(xue)(xue)(xue)。藥物療(liao)法包括止(zhi)血(xue)(xue)(xue)(xue)(xue)藥、抗(kang)纖溶(rong)藥、用以(yi)抵抗(kang)纖維蛋白溶(rong)解并(bing)且(qie)抑(yi)制(zhi)纖溶(rong)酶原激(ji)(ji)活因子(zi),達到(dao)止(zhi)血(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)目(mu)的(de)(de)(de)(de)、前(qian)列(lie)腺(xian)素(su)(su)(su)合成酶抑(yi)制(zhi)劑(ji),抑(yi)制(zhi)前(qian)列(lie)腺(xian)素(su)(su)(su)的(de)(de)(de)(de)生(sheng)成,抵制(zhi)前(qian)列(lie)腺(xian)素(su)(su)(su)的(de)(de)(de)(de)促進出血(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)機制(zhi);使用凝(ning)血(xue)(xue)(xue)(xue)(xue)因子(zi)如纖維蛋白原和血(xue)(xue)(xue)(xue)(xue)小板。除了上(shang)述止(zhi)血(xue)(xue)(xue)(xue)(xue)方法之外,還可(ke)(ke)以(yi)通(tong)過(guo)調節月經周期,重(zhong)建規律月經,也可(ke)(ke)以(yi)采用促排卵療(liao)法,避免(mian)功血(xue)(xue)(xue)(xue)(xue)的(de)(de)(de)(de)復發。
對于排卵型功(gong)血的治療(liao),臨床上采用雄(xiong)激素療(liao)法、孕激素周期療(liao)法等,以抑(yi)制月經過多;輔助(zhu)黃體功(gong)能(neng),如孕酮療(liao)法。
中醫(yi)在治(zhi)療(liao)功能性(xing)子宮(gong)出血上(shang)具有其(qi)優(you)越性(xing),中醫(yi)認為(wei)(wei)功血屬于“崩漏(lou)(lou)”。婦女不(bu)在行經期間(jian)陰道突(tu)然大量(liang)出血,或淋漓下(xia)(xia)血不(bu)斷者(zhe)(zhe),稱(cheng)為(wei)(wei)“崩漏(lou)(lou)”,前者(zhe)(zhe)稱(cheng)為(wei)(wei)“崩中”,后(hou)者(zhe)(zhe)稱(cheng)為(wei)(wei)“漏(lou)(lou)下(xia)(xia)”。若經期延長達2周以上(shang)者(zhe)(zhe),應屆(jie)崩漏(lou)(lou)范疇,稱(cheng)為(wei)(wei)“經崩”或“經漏(lou)(lou)”。崩漏(lou)(lou)之(zhi)病,本乎一證,輕者(zhe)(zhe)謂之(zhi)漏(lou)(lou)下(xia)(xia),甚者(zhe)(zhe)謂之(zhi)崩中。是(shi)因為(wei)(wei)沖任(ren)失(shi)其(qi)固攝(she)引起,多(duo)是(shi)因為(wei)(wei)血熱、氣虛(xu)、血瘀等(deng),氣虛(xu)包括腎(shen)氣虛(xu)和脾(pi)氣虛(xu),脾(pi)主統血,脾(pi)虛(xu)則(ze)(ze)血失(shi)固攝(she),遂(sui)成崩漏(lou)(lou)。臨床(chuang)上(shang)根據月(yue)經血的(de)(de)(de)顏色、量(liang)、質變化以及全身(shen)證候辨明寒、熱、虛(xu)、實(shi)。治(zhi)療(liao)應根據病情的(de)(de)(de)緩急輕重、出血的(de)(de)(de)久暫,采用“急則(ze)(ze)治(zhi)其(qi)標(biao),緩則(ze)(ze)治(zhi)其(qi)本”的(de)(de)(de)原(yuan)則(ze)(ze),靈活運用塞流、澄源、復(fu)舊三法。
對(dui)于血(xue)熱(re)(re)型(xing)(xing)的崩漏,主方(fang)(fang)采(cai)(cai)用(yong)(yong)清(qing)熱(re)(re)固(gu)經湯(tang)(tang);血(xue)瘀型(xing)(xing)采(cai)(cai)用(yong)(yong)逐瘀止崩湯(tang)(tang);脾虛(xu)(xu)型(xing)(xing)采(cai)(cai)用(yong)(yong)固(gu)沖(chong)湯(tang)(tang);腎虛(xu)(xu)型(xing)(xing)采(cai)(cai)用(yong)(yong)大補元煎。傅氏辨治育齡崩漏,血(xue)熱(re)(re)型(xing)(xing)屬虛(xu)(xu)熱(re)(re)者(zhe)(zhe),方(fang)(fang)選兩地(di)湯(tang)(tang)加(jia)(jia)減(jian);實(shi)熱(re)(re)者(zhe)(zhe)方(fang)(fang)選用(yong)(yong)丹梔消(xiao)遙散加(jia)(jia)減(jian);氣虛(xu)(xu)型(xing)(xing)方(fang)(fang)選寄生膠(jiao)艾湯(tang)(tang)加(jia)(jia)減(jian);血(xue)瘀沖(chong)任型(xing)(xing)方(fang)(fang)選血(xue)府逐瘀湯(tang)(tang)加(jia)(jia)減(jian)。
除了藥(yao)物(wu)治療(liao)(liao)(liao)外,患者(zhe)要注意飲食(shi)和(he)休息,根據寒(han)熱虛實(shi),做到虛者(zhe)補,實(shi)者(zhe)泄(xie)。食(shi)療(liao)(liao)(liao)與藥(yao)療(liao)(liao)(liao)相結合,對于疾病的恢(hui)復意義(yi)重(zhong)大。
對藥(yao)物療效不佳或不宜(yi)用(yong)藥(yao)、無生育要求的患者(zhe),可采用(yong)手(shou)術(shu)治療。主(zhu)要分為兩類手(shou)術(shu)即(ji)子宮(gong)(gong)內膜去除手(shou)術(shu)和子宮(gong)(gong)切除手(shou)術(shu)。
1、 功(gong)(gong)能性(xing)子(zi)宮出(chu)血危害大(da)(da),做好護理很(hen)關鍵,做功(gong)(gong)能性(xing)子(zi)宮出(chu)血護理的(de)時(shi)候,患者要(yao)特別注(zhu)意飲食(shi),要(yao)制定適合自己的(de)飲食(shi)計劃,保持營養均衡(heng),不要(yao)挑食(shi),多吃一(yi)些(xie)含鐵的(de)食(shi)物(wu),這樣對于功(gong)(gong)能性(xing)子(zi)宮出(chu)血的(de)治療有很(hen)大(da)(da)的(de)幫助(zhu)。
2、 功能性子宮出血(xue)(xue)是比較嚴重的疾病(bing),病(bing)情加重的時(shi)候(hou)(hou),出血(xue)(xue)量會(hui)很多,這樣會(hui)導致(zhi)患者出現(xian)貧血(xue)(xue),所以這個時(shi)候(hou)(hou),患者要(yao)(yao)自(zi)行觀察自(zi)己的身體,臥床休(xiu)息,配合醫生(sheng)的治療,必要(yao)(yao)的時(shi)候(hou)(hou)要(yao)(yao)進(jin)行止血(xue)(xue)和輸血(xue)(xue)。
3、 功能性(xing)子宮(gong)出(chu)血(xue)患者要定時(shi)到醫院做(zuo)檢查(cha),還要記住醫生要求,按時(shi)服(fu)用抗生素藥物(wu),預(yu)防感染(ran),還要保(bao)持外陰的清潔,保(bao)持心情舒暢,積極樂觀的面對病情,這(zhe)樣才能將功能性(xing)子宮(gong)出(chu)血(xue)治療好(hao)。